Cryo-EM Single Particle Analysis

cryo_em Scientific Instrumentation Electron
View Benchmarks (1)

Forward-Model Signal Chain

Each primitive represents a physical operation in the measurement process. Arrows show signal flow left to right.

C Convolution D Detector
Spec Notation

C → D

Benchmark Variants & Leaderboards

Cryo-EM Single Particle Analysis

Cryo-EM Single Particle Analysis

Full Benchmark Page →
Spec Notation

C → D

Standard Leaderboard (Top 10)

# Method Score PSNR (dB) SSIM Trust Source
🥇 DiffusionCryo 0.895 39.8 0.963 ✓ Certified Luo 2024
🥈 CryoSTAR 0.866 38.4 0.952 ✓ Certified Yang 2024
🥉 CryoFormer 0.839 37.1 0.941 ✓ Certified Gao 2024
4 CryoGEM 0.799 35.2 0.924 ✓ Certified He 2023
5 cryoDRGN 0.762 33.7 0.901 ✓ Certified Zhong 2021
6 IsoNet 0.709 31.4 0.871 ✓ Certified Liu 2021
7 cryoSPARC 0.630 28.1 0.823 ✓ Certified Punjani 2017
8 RELION-3D 0.571 25.8 0.782 ✓ Certified Scheres 2012
9 CTFFIND4 0.479 22.3 0.714 ✓ Certified Rohou 2015
Mismatch Parameters (4) click to expand
Name Symbol Description Nominal Perturbed
defocus_error d_e Defocus error (nm) 0.0 100.0
astigmatism a Astigmatism (nm) 0.0 20.0
beam_tilt b_t Beam tilt (mrad) 0.0 0.2
ice_thickness_variation i_t Ice thickness variation (nm) 50.0 56.0