Hidden

DESI Mass Spectrometry Imaging — Hidden Tier

(5 scenes)

Fully blind server-side evaluation — no data download.

No data downloadable. Algorithm runs server-side on hidden measurements.

Package algorithm as Docker container / Python script. Submit via link.

Containerized algorithm accepting y + H, outputting x_hat + corrected spec.

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True spec hidden — blind evaluation, only ranges available.

Parameter	Spec Range	Unit
spray_angle_error	-0.7 – 2.3	deg
solvent_flow_variation	-2.1 – 6.9	-
ion_suppression_(matrix_effect)	-7.0 – 23.0	-
spatial_resolution_degradation	-7.0 – 23.0	-

#	Method	Score	PSNR	SSIM	Consistency	Trust	Source
1	MSIFormer + gradient	0.744	30.72	0.927	0.83	✓ Certified	Kalinichenko et al., Nat. Methods 2023
2	DiffusionMSI + gradient	0.723	30.4	0.923	0.75	✓ Certified	Palmer et al., Nat. Methods 2024
3	MSI-GAN + gradient	0.656	25.97	0.831	0.82	✓ Certified	Yang et al., Anal. Chem. 2021
4	MSI-NMF + gradient	0.548	21.83	0.683	0.78	✓ Certified	Blanco et al., Anal. Chem. 2013
5	MSI-PCA + gradient	0.542	21.2	0.655	0.84	✓ Certified	Alexandrov et al., J. Bioinform. Comput. Biol. 2010
6	DeepMSI + gradient	0.535	21.03	0.647	0.83	✓ Certified	Gruber et al., Anal. Chem. 2021
7	SpaMSI-Net + gradient	0.528	21.33	0.661	0.75	✓ Certified	Rappez et al., Nat. Methods 2021
8	MSI-TV + gradient	0.523	20.34	0.615	0.87	✓ Certified	Fonville et al., Bioinformatics 2012
9	MSI-Hotelling + gradient	0.438	17.59	0.48	0.85	✓ Certified	Deininger et al., Proteomics 2011

Scenes: 5

0.4 × PSNR_norm + 0.4 × SSIM + 0.2 × (1 − ‖y − Ĥx̂‖/‖y‖)

PSNR: 40% SSIM: 40% Consistency: 20%